Myelin and Lipid Composition of the Corpus Callosum in Mucopolysaccharidosis Type I Mice
نویسندگان
چکیده
منابع مشابه
Low-cost, rapidly-developed, 3D printed in vitro corpus callosum model for mucopolysaccharidosis type I
The rising prevalence of high throughput screening and the general inability of (1) two dimensional (2D) cell culture and (2) in vitro release studies to predict in vivo neurobiological and pharmacokinetic responses in humans has led to greater interest in more realistic three dimensional (3D) benchtop platforms. Advantages of 3D human cell culture over its 2D analogue, or even animal models, i...
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Myelin enhancement of Multiple sclerosis model with gold nanoparticles into the corpus callosum
Objective(s): With no substantial cost, we injected L-arginine into the rat’s corpus callosum (CC) to create animal model of multiple sclerosis (MS) and investigated the pre-injection effect of gold nanoparticles (GNPs). Materials and Methods: Adult male Wistar rat (250-300 g) was surgically cannulated at the CC, and after recovery it was injected L-arginine (3-200 µg/rat, intra-CC) once ...
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The densities of fibers of different sizes were calculated in ten regions of the corpus callosum of twenty human brains (ten females, ten males). Light microscopic examination revealed a consistent pattern of regional differentiation of fiber types in the corpus callosum. Thin fibers are most dense in the anterior corpus callosum (genu), and decrease in density posteriorly towards the posterior...
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ژورنال
عنوان ژورنال: Lipids
سال: 2020
ISSN: 0024-4201,1558-9307
DOI: 10.1002/lipd.12261